The best thing about Copic ciao markers is their refillable ink bottles. You can re-fill these bottles nine times, so it’s easy to replace them. The caps are child-proof and won’t obstruct the airway if swallowed. The chisel tip is slightly larger than the medium-broad nib, so you should make sure to replace them with the right size.
The smallest and cheapest of the Copic ciao markers, these ciao markers are ideal for beginners. They’re filled with Copic’s ultra-soft ink, have a super brush nib, and come in a handy oval shape. This makes coloring easy and keeps the ciaos from rolling away. These chalk markers are the perfect way to get started with digital art. And you won’t need to worry about breaking or wasting any ink, because you can always replace the marker with a new one.
The ciao markers also come with a convenient storage pouch. This case helps you store them easily and conveniently. The marker also has a chisel nib that mimics an old-school drawing nib. This type of tip is perfect for sketching and drawing. The chisel is the only one compatible with the Copic ciao marker. Moreover, the ciaos are small and can fit into a pocket.
The ciao markers are made for a beginner. They’re not as large as the ciaos, but they still feature the same brilliant ink as the sketch markers. The difference lies in the size of the marker barrel. They’re also available in several color collections. Another unique aspect of a ciao is the double-ended design. The double-ended design features a flexible Super Brush tip on one end and a medium-broad nib on the other. It’s great for fine detail and sweeping strokes.
The ciao markers have a single side for both sides. This allows you to use them on either side of the canvas. The ciao is ideal for painting on canvas. The two types of CIAO are not the same, but they have similar characteristics. The CIAO is made to last a lifetime and is made with children in mind. The chisel is the most popular tip for the Ciao, while the chisel is used for drawing.
The ciao is the cheapest of the Copic models. Its color range is excellent, and it’s easy to blend colors. Its round design is great for sketchbooks. These markers can be bought anywhere. They have become widely available in the US. And they are a popular choice among artists and hobbyists. These are the most affordable markers available today, and they are easy to find. It’s not uncommon for a beginner to have difficulty finding the perfect color.
Among the Copic ciao markers products, the Ciao offers the greatest variety of colors. There are three types of these Copics: the Classic, the Sketch, and the Ciao. The Classic is the most expensive, with 214 colors. It is the most traditional type, and has been used for decades by professional illustrators. It is the most affordable and versatile among the Copics. This color range is the best!
The Ciao is a great choice for beginning artists. It is relatively inexpensive compared to the Sketch, and its ink flow is excellent. It’s best for beginners, as it can be refilled up to 15 times. And it comes with 180 different colors! If you’re looking for an affordable Copic ciao markers, the Ciao is a great option. The Ciao is a great option if you want to create artwork for children, but also if you’re looking for a good-looking marker for yourself.
The Ciao is a great choice for beginner artists, because it offers a great price-value ratio. While it’s not as flexible as the Sketch, it’s still a great option for practicing strokes and basic artwork. The brand has been known for producing high-quality, nontoxic, and long-lasting ink for many years. The Copic range is not just for adults, though; it’s also great for kids.
The Ciao is a good choice for beginners. Unlike the Sketch, this pen doesn’t have a cap. But the other style has a laser-etched labeling that is more durable. The Copic Airbrush system is great for large areas of work, and is compatible with Copic ciao markers and Sketch markers. Aside from the airbrushing system, the other style is better for children.
Zombie Drugs to Treat COVID-19 Long-Haulers Syndrome
Long-haulers experience symptoms that limit normal function long after clearing the coronavirus. These symptoms include shortness of breath, fatigue, heart problems, dizziness, headaches, and impairments in mental health and cognition. An estimated 5% of people infected with COVID19 develop Long-Haulers Syndrome regardless of age and severity of symptoms during the initial infection phase. There are currently no effective treatments for long COVID, although research indicates that lingering inflammation is the main cause of most symptoms. New research indicates that coronavirus-infected cells transform into zombie cells and that this conversion is linked to long-term inflammation in long-haulers. Physicians have therefore begun to clinically test whether drugs that kill zombie cells are suitable for the treatment of Long-Haulers Syndrome. Below we will take a closer look at zombie cells and the freely available plant-based drugs used to kill these cells in Long-Haulers Syndrome patients.
Long COVID symptoms are linked to inflammation
The exact cause of Long-Haulers Syndrome has long been a mystery. But recent evidence indicates that many long COVID-19 symptoms stem from the persistence of inflammation after the SARS-CoV-2 virus has been cleared. While inflammation is part of the normal response to viral infections that helps the immune system clear the virus, there is no reason for inflammation to persist when the virus has been eliminated. So why do long-haulers maintain the inflammatory state? Some researchers speculated that this might have something to do with the zombie cells that the virus leaves behind as these cells have been shown to induce local or systemic (whole-body) inflammation.
Coronavirus-infected cells turn into pro-inflammatory zombie cells
The laboratory of Dr. Clemens Schmitt in Germany elegantly demonstrated that SARS-CoV-2 stresses the cells it infects to the extent that these cells convert into zombie cells. Shortly thereafter a Japanese study led by Dr. Eiji Hara confirmed these findings. Zombie cells are the nickname for senescent cells, which are known for their inability to proliferate and the production of a so-called senescence-associated secretory phenotype (SASP).
The SASP consists of hundreds of secreted factors, typically including not only cytokines, chemokines, proteases, growth factors, and lipids, but also noncoding nucleotides and exosomes. Studies over the past decade found that SASP factors can induce inflammation, fibrosis, coagulation, tissue damage, and stem cell dysfunction. What is remarkable with COVID-19 is that coronavirus-infected zombie cells somehow bring neighboring non-infected healthy cells into a zombie-like state, thereby further amplifying the SASP and the degree of local and systemic inflammation it causes.
Zombie cells negatively impact health and longevity
The existence of zombie cells was first noticed in the early 1960s by Leonard Hayflick. These intriguing cells were long speculated to be associated with aging and diseases that occur mostly at an advanced age. However, it took more than half a century for researchers to come up with evidence to support this theory.
The breakthrough came from 2011 and 2016 studies in mice published in the journal Nature, both from the laboratory of Dr. Jan van Deursen. These studies showed that zombie cells accumulate with aging throughout the body and that their elimination can slow aging, prevent age-related diseases, and promote longevity. The killing of zombie cells was referred to as “senolysis” and the drugs that do so were dubbed senolytics. Dr. Jan van Deursen work spurred the development of such drugs, which in preclinical studies (mostly studies in mice) have been shown to slow or prevent major diseases of aging, including atherosclerosis, dementia, osteoarthritis, and macular degeneration.
Two classes of zombie drugs for the treatment of COVID-19
Both the abovementioned COVID-19 studies used fisetin and quercetin to eliminate zombie cells. These natural compounds are flavonoids that are found in fruits and vegetables. They are freely available in stores as supplements. Both these zombie drugs were very effective in preventing death if they were administered within days after being infected with the coronavirus.
A zombie drug that falls within a different class is navitoclax. It is a small molecule that does not exist in nature and is produced by pharmaceutical companies. Navitoclax eliminates zombie cells by inhibiting proteins that belong to the BCL2 family. Zombie cells are so aberrant that they rely on this family of proteins to stay alive. In contrast to fisetin and quercetin, navitoclax had a limited impact on the survival of coronavirus-infected rodents.
Given the different outcomes of distinct classes of zombie drugs, it should be noted that both fisetin and quercetin have long been studied by researchers for a wide variety of health benefits. These earlier studies found both flavonoids to have powerful antioxidant, anti-inflammatory, and immunomodulatory properties. It is therefore conceivable that it is these properties that provide protection against coronavirus rather than their ability to kill zombie cells.
Fisetin clinical trials
Some have reasoned that the question as to how fisetin and quercetin provide protection against COVID-19 infection has become somewhat of a moot point with the availability of powerful vaccines and antivirals such as the Pfizer drug paxlovid. It is hard to argue against this, but the potential value of zombie drugs in the post-infectious phase of COVID-19 remains very high given the lack of successful treatments for Long-Haulers Syndrome.
There seems great promise for the use of zombie drugs for the treatment of long COVID-19 as highlighted by a recent new rodent study in which researchers specifically looked at inflammation that persists after coronavirus has been cleared, as is the case with Long-Haulers Syndrome. Using a zombie drug that inhibits BCL-family members on animals that had fully cleared the virus, the researchers markedly reduced the inflammation that persisted. The disadvantage of a zombie drug that inhibits BCL-family members is that it has serious potential side effects. Therefore, it is not freely available and only approved for the treatment of certain cancers.
This contrasts fisetin and quercetin, which both have an excellent safety profile and have been popularized to fight off aging and aging-related ailments through the work of Dr. James Kirkland. He is a physician and is currently involved in a dozen or so clinical trials testing the potential benefits of fisetin and quercetin, the latter of which is typically administered in combination with a low dose of the cancer drug dasatinib. Importantly, one of these trials is looking at the potential beneficial effects that the most unrestricted zombie drugs, fisetin, may have on long-term recovery of COVID-19 infected nursing home residents that had no, mild, or moderate symptoms. This trial should clarify the extent to which fisetin may be suitable for use by people that suffer from long COVID-19.
Fisetin as a natural substance and used as a drug
As mentioned, fisetin (also referred to as 3,3′,4′,7-tetrahydroxyflavone) is a bioactive flavonol molecule found in fruits and vegetables. The average daily intake of fisetin through food consumption is estimated to be 400 micrograms. The highest concentration of fisetin was found in strawberries (160 microgram per gram strawberries) followed by apple (26.9 microgram per gram apple), persimmon (10.5 microgram per gram persimmon), onion (10.5 microgram per gram onion ), grape (3.9 microgram per gram grape), kiwi (2.0 microgram per gram kiwi) and cucumber (0.1 microgram per gram cucumber).
The typical dose of fisetin that is used in ongoing clinical trials is 20,000 microgram per kg body weight, which amounts to nearly 1,500,000 micrograms or 1.5 grams of fisetin for a 165-pound person. This is about 3,750 times higher than the daily intake of fisetin through food. One may find the amount somewhat alarming. However, the over-the-counter (online) price of a 0.5 gram capsule of fisetin is as little as just over a dollar.
In the human COVID-19 trial, fisetin is only administered 4 times: first on two consecutive days and then the same one week later. The idea behind administering such few doses is the assumption that two short bursts of fisetin are sufficient to eliminate zombie cells and that, once they are gone, it takes a long time for them to come back to the extent that they can be of any negative impact on health again. The half-life of fisetin is in the order of 5-6 min which is considered very short for a drug. This means that zombie cells must promptly die after just a very brief encounter with the drug, and further adds to the mystery of how fisetin could possibly kill these cells.
It is important to keep in mind that fisetin has been reported to have a wide spectrum of molecular targets that belong to the most central cellular signaling pathways. For instance, it has been shown to inhibit mTOR, WNT, ERK, NFkappaB, and PI3K, while stimulating AMPK and TSC1/2. With its prominence as a zombie drug rising, it will be critical for researchers to decipher how it actually kills these cells. Of the 20 fisetin clinical trials that are listed on ClinicalTrials.gov, only a few are not directly linked to zombie cells. This is somewhat surprising given that for many years fisetin has been shown to be a chemotherapeutic agent in several types of cancers as well as a neuroprotective agent.
It will be interesting to see the outcomes of all the ongoing trials with fisetin. Although it will be difficult to interpret the mechanism of action if there is a positive outcome in any of these trials, the hope is that funds will be made available later to begin to decipher these mechanisms for each condition where fisetin is showing a therapeutic effect.
Jan van Deursen – Almost everyone in the research and scientific field or even interested in this niche would be familiar with this name. A driven and career-focused American scientist constantly working to create cutting-edge therapies to treat age-related ailments.
Born and raised in the Netherlands, Jan Van Deursen received his Ph.D. in 1994. Like many other scientists, Jan Van Deursen then moved to the US to pursue fresh research prospects.
Jan Van Deursen developed the method for stem cell editing in mice while working toward his doctorate. Jan Van Deursen was offered the opportunity to start his lab at St. Jude Children’s Research Hospital because of his exceptional understanding.
If we talk about some worthwhile studies /excerpts from research carried out by Jan Van Deursen, then overall, it reveals Jan Van Deursen’s applicability and passion for science. Let’s dive in t learn about his applicability in light of Jan Van Deursen’s studies/ and research-based solutions.
Relevancy of Jan Van Deursen in His Studies For Science
The main interest of Jan Van Deursen lies in understanding the mechanisms that lead to cell death and the aging process. His laboratory’s investigation concentrated on the role of protein concentration changes in senescence and the aging of cells and tissues.
The results of this study have directly led to the development of anti-aging drugs that target these proteins in particular. Together with their other founding coworkers, Dr. Jan van Deursen was one of the people who contributed to the creation of Unity Biotechnology. The development of medications intended to address issues related to aging is this company’s primary area of concentration.
Cellular Senescence & Aging
Dr. Jan van Deursen as is regarded by many as one of the world’s leading authorities on cellular senescence, a crucial aspect of aging. Jan Van Deursen’s research suggests that eliminating senescent cells could significantly slow down or stop aging. One possible justification for such behavior is the desire to put off getting old. It could result in identifying drugs that greatly lengthen the average human lifetime and enhance the quality of life for the elderly.
Our understanding of the aging process and the possibility for drugs to slow down or reverse its effects has expanded thanks to the talents of Dr. Jan Van Deursen, a researcher significantly. One day, the results of his labors might extend the average human lifetime and enhance the quality of life for the elderly.
If Dr. Jan van Deursen and his team’s study is successful, it’s feasible that in the not-too-distant future, all of us may be able to live longer, healthier lives free of aging-related ailments. The discoveries made by Dr. Jan van Deursen and his team find many reasons to be optimistic about the future. The disease’s progression might be slowed down, turned around, or completely stopped.
What Concepts Does Jan Van Deursen Bring to the Future About Aging?
Jan Van Deursen concludes that as cells age, the protective caps at the ends of chromosomes, known as telomeres, reduce in length. This finding is our way of expressing thanks for helping us better understand aging and develop new therapies for diseases that develop as we age.
Dr. Jan Van Deursen studies the molecular processes contributing to aging and cell death. Jan Van Deursen’s research team has focused, in particular, on how changes in protein abundance may lead to cell death and tissue senescence.
Anti-aging medications that stop the effects of these proteins were created because of these findings. Another firm that produces anti-aging drugs, Unity Biotechnology, was founded with help from Dr. Jan van Deursen. The first osteoarthritis medication, UBX0101, has begun clinical testing. Jan Van Deursen enjoys riding and skiing as leisure when he’s not busy being a husband and a parent to three kids.
Because of his contributions to the subject of aging research, a topic on which his work has had a significant and advantageous impact, Jan Van Deursen has received a great deal of respect in the scientific community. His research on telomeres and how they relate to aging has received multiple awards, including the coveted Lasker Award.
Have you ever wondered what Dr. Jan Van Deursen believes about the potential future of science?
Jan Van Deursen believes the future of science can be fruitful with advanced technology and how it can upgrade the medicine field in numerous ways, including; telehealth, information revolution, latest health equipment, immunotherapy, deep tissue imaging, etc.
Moreover, Jan Van Deursen is abreast of the most recent developments in medical science, keeping an eye on how they might help those with cancer and other debilitating age-related illnesses. These advancements will benefit patients by enhancing their quality of life and easing their diseases.
Although the learning curve for medical researchers today is steep, amazing advances will be made because of human ingenuity. People will live longer thanks to recent medical advancements.
Dr. Jan Van Deursen is widely regarded as a pioneer in studying aging and its associated diseases. Jan Van Deursen has concentrated his research lately on senescent cells and the role they play in the aging process. These cells can no longer divide; thus, they cannot give the body the proteins it needs.
As a pioneer in the area of study that focuses on aging and diseases that are frequently linked to it, his findings may open the door to cutting-edge therapies that will raise the standard of living for those in their later years.
Senescent cell proliferation is primarily responsible for age-related conditions like frailty, cataracts, and dementia. A team under the direction of Dr. Jan Van Deursen laid the foundation for it. It is well known that senescent cells have a role in many aging illnesses.
Dr. Jan van Deursen is eager to conduct more studies on senescent cells and how they affect aging. Jan Van Deursen is optimistic that if we can focus on these cells, we might be able to find solutions to the issues brought on by aging. Jan Van Deursen plans to look into two more probable causes of aging: inflammation and mitochondrial malfunction.
Industrial surge protection can be a crucial element in keeping equipment safe. These surges can come from various sources, including lightning and utility switching operations. They can also originate from the unintentional grounding of electrical conductors. In addition, electrical surges can enter a facility through a telecommunications or Internet cable. However, while most electrical surges originate from outside sources, 80 percent are generated from equipment inside the facility.
Industrial surge protection devices are typically wired in one of two ways. One method, called an in-line connection, directly routes the load current to the surge protective device. The parallel connection method involves placing a separate wire between the surge protective device and the main load wire. In either case, extra line length will be required between the surge protective device and the wire. In both cases, industrial surge protection is an important safety component.
To ensure that industrial surge protection devices have high levels of protection, look for the following certifications. Underwriters Laboratories (UL) certification means that the device has passed strict testing requirements. While many industrial surge protection devices meet these standards, these may not always match the required level of protection. For example, in a lightning-prone area, a special engineering analysis will be required to determine the appropriate level of protection.
The demand for electronic equipment is increasing around the world. Demand has been increasing in developing countries due to industrialization and higher disposable income. This is driving demand for industrial surge protection devices. Embedded microprocessors, programmable logic controls, and electronic circuitry that automate industrial processes are particularly susceptible to power surges. These surges can cause catastrophic failures, interrupt processes, and premature equipment aging. Industrial surge protection can mitigate these risks and keep equipment running reliably. You can shop for industrial surge protector from Zerodt.
Industrial surge protection is essential to a comprehensive power surge protection strategy. A comprehensive protection scheme will include multiple SPDs located strategically throughout a plant. Ideally, a facility would have three to four levels of protection. In addition, all critical loads should have onboard surge protection. A high-quality industrial surge protection system will be able to protect equipment from damage caused by power surges.
In addition to reducing power consumption, industrial surge protection devices also minimize the risk of voltage spikes. This is because they change their impedance as voltage increases, and these SPDs turn off when voltage levels drop below the threshold. These devices should include temperature fuses and circuit breakers. Many of these devices are equipped with LED lights to help prevent dangerous situations from occurring.
Quarter-wave coax surge arrestors feature a tuned quarter-wavelength short-circuit stub. These devices are suitable for RF signals exceeding 400 MHz, and they have coax terminals compatible with common coax cable connectors. These devices are particularly suitable for applications where the ability to withstand a wide range of voltages is important.
Industrial surge protection is an important part of protecting equipment in industrial settings. Electricity surges can lead to equipment failure, financial loss, or damage. This is why the NLSI has created guidelines for the safety of workers in these settings. The best surge protection devices will divert excessive voltage to the ground. You should also check the specifications of each industrial surge protection device to ensure that it is suitable for your environment. There are many different sources of power surges.
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